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Crocomire is a creature in the SNES video game Super Metroid, the third title in the Metroid series. It's a large red species with six arms and legs that could only be killed in the game by falling into lava. Samus Aran would be able to do this by shooting enough missiles into its mouth, each time making it scoot back a little more. Eventually it would fall in the lava, which would thus burn all of its skin, leaving only a set of bones.
Once you did so, the skull of the creature would be shot into a previously blocking wall, destroying, and thus allowing you to move on.
The species presumably became extinct once Zebes, the planet the species was found on, was destroyed.