Dr. Mario in this game is more akin to Dr. Mario 64 then other versions of the game. There is a mode you unlock that has you turn the GBA so that the screen is longer vertically. In order to get this mode, you must complete the twentieth level in single player. When the player downloads a version of the game to another Game Boy Advance system, they'll be given NES style graphics and sound.
Puzzle League is a remake of the games Panel de Pon, Tetris Attack, and Pokémon Puzzle League. It isn't similar to any of the three games, but its appearance can be attributed to the Game Boy Advance download version from Nintendo Puzzle Collection. Like Dr. Mario, a vertical version of the game is present where you tilt your Game Boy Advance. In order to get this mode, you must score a total of ten thousand points or more in the game's endless mode.