Dr. Mario Online Rx is a WiiWare video game initially released in 2008. The game was released in the WiiWare's launch window, and is basically a Dr. Mario remake featuring plenty of extras including online play and Virus Buster, a mini-game that was featured in Brain Age 2 for the Nintendo DS.
Players are allowed to use their Miis instead of Dr. Mario, even while playing online.
In the main game, players must drop pills on viruses bellow in order to destroy them. In all, there are three different colored viruses, and to kill one you'll have to drop three pill segments on top of a virus of the same color in order to destroy it. Each pill has two separate or same colored segments.
Once you complete a level, you'll be required to go to the next, which will inevitably be harder than the previous puzzle.