In the game, the city is known as the most advanced city in not only the world or galaxy, but the most advanced city in the entire known universe. It is greatly known to be a major place for F-Zero racing. The race circuit is placed high above along with the city's tallest structures. Mute City is very close in design and architecture to Aeropolis.
The city contains over one billion people, and thus has an awful amount of pollution, making the entire city always black and raging with thunder storms. Scientists there though have been able to harness the energy of these storms, which not only allows them to power Mute City and other cities on Earth, though hundreds of other planets that need power.
The races that live in Mute City consist of multiple alien beings - thousands in fact. Obviously, the city largely populated with humans as well.