Punch-Out!! may refer to:
- Punch-Out!! (series) - a video game series.
- Punch-Out!! (arcade) - A 1984 arcade video game.
- Punch-Out!!: Gold Edition - The first version of Mike Tyson’s Punch-Out!! to release to the public.
- Mike Tyson's Punch-Out!! - A 1987 NES video game.
- Punch-Out!! Featuring Mr. Dream - A 1990 reprint of the NES game without Tyson.
- Punch-Out!! (Game & Watch) - A 1984 Game & Watch game. Also known as Boxing.
- Punch-Out (Wii) - A 2009 Wii video game.