Dr. Mario series
In Dr. Mario, Dr. Mario must use his Megavitamins to stop the spread of the Viruses. The three types of Viruses are Fever (Red), Chill, (Blue) and Flu (Yellow). To destroy the viruses, Mario must line up a virus with two like colored segments of Megavitamins, two like colored Viruses and a Mega Vitamin or some combination of the above. After Dr. Mario eliminates all Viruses in a jar, he would move onto the next jar.
Mario & Luigi Series
Viruses also appear in Mario and Luigi: Superstar Saga where they appear in Woohoo Hooniversity. When encountered, several of them will attack the Bros. To defeat them, Mario or Luigi must strike them to get them to change colors. When two or more are the same color, they are defeated. They also appear in Mario & Luigi: Dream Team, and the aforementioned game's remake, Mario & Luigi: Superstar Saga + Bowser's Minions.
Super Smash Bros. series
- "These contagious viruses make life difficult for Dr. Mario. They infect everything they come into contact with, and the good doctor must attempt to neutralize them with his trusty megavitamins. Dr. Mario can stop these pesky germs by lining up the megavitamin capsules of the same color with the nasty microorganism."
Different Viruses appear in Dr. Wario, a mini game in WarioWare, Inc.: Mega Microgames$!.
The Driver Virus in Mario Kart Arcade GP looks like Chill with swirly eyes. The Driver Virus slows down opposing drivers.
|Major villains||Donkey Kong | Bowser | Foreman Spike | Wart | Koopalings (Ludwig von Koopa | Lemmy Koopa | Roy Koopa | Iggy Koopa | Wendy O. Koopa | Morton Koopa Jr. | Larry Koopa) | Tatanga | Virus | Wario | Kamek | Baby Bowser | Smithy | Big Bob-omb | Waluigi | King Boo | Shadow Mario | Petey Piranha | Bowser Jr. | Cackletta | Fawful | Antasma | Sir Grodus | Lord Crump | Shadow Queen | Princess Shroob | Count Bleck | Dimentio | Pom Pom | Boom Boom | Bowser Soul | Topper | Hariet | Rango | Spewart | Madame Broode|
|Minor villains||Blooper | Bob-omb | Boo | Bullet Bill | Buzzy Beetle | Chain Chomp | Cheep Cheep | Dry Bones | Goomba | Hammer Bros. | Koopa Paratroopa | Koopa Troopa | Lakitu | Magikoopa | Monty Mole | Ninji | Piranha Plant | Pokey | Shroob | Shy Guy | Snifit | Spiny | Thwomp | Whomp | Wiggler|